This game is likely to give a good indicator to just how strong Chelsea are this campaign and if they can take something on Sunday afternoon, will show they are real title contenders.
With United having the chance to close the gap on their opponents though, they have the incentive to go and grab the points as well.
Both these sides came through tough European games in the week, with Chelsea going down 2-1 to Ukrainian side Shakhtar Donesk, while the Red Devils came through a tough test of character at Old Trafford, finally securing a 3-2 win over Braga.
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Sir Alex Ferguson’s men are making a real habit of starting a game slow and going a goal down, and it is clear the loss of Nemanja Vidic has definitely affected their defence, which now looks very brittle.
They have often still managed to win matches though, defeating Newcastle 3-0 in their last away trip, but against Chelsea right now – any mistakes will be punished and United could have too much to do if they are not at the races early on.
The Blues have a superb array of attacking talent this season and Juan Mata is only enhancing his reputation as one of the best players in the league.
The Spaniard is a world-class playmaker that is clearly making the team tick in midfield, as he proved at Tottenham Hotspur last weekend what a superb finisher he is as well by grabbing himself two goals.
Held together with Edin Hazard and Oscar the Blues look to have found some stability in the centre of midfield.
Mata can be backed at 8/1 with Bet365 to score the first goal, which is sure to see plenty of support from punters.
The away side have the dynamic duo of Robin Van Persie and Wayne Rooney though, who already look to have a superb understanding with each other, despite not playing a great deal of football together.
Javier Hernandez has also thrown his name into the hat with a match winning performance midweek, and the Mexican will be hoping for a starting birth, at least ahead of Danny Welbeck in the pecking order.
At odds of 9/1 to score first with Paddy Power he looks a little on the large side, considering his scintillating form in the Champions League.
The London club are one of only two sides not to be beaten in the league this campaign, so Manchester United must be at their best.
With so many fantastic players on show and the stakes being so high, this game is not likely to disappoint. Stamford Bridge is sure to be rocking on Sunday afternoon and it is the perfect way to round off another weekend of Premier League football.