Looking at United to begin with, they certainly look to be in great shape to regain the Premier League title.
They have won their last five matches across all competitions and seem to have done some great business in the transfer market to bring silverware back to Old Trafford.
Many people are now talking about Robin Van Persie of course, which is no surprise as he has already netted five times in the top flight and already got himself a hat-trick. Van Persie is sure to start in this one, and Wayne Rooney could also feature after his thigh injury.
Sir Alex Ferguson has never lost to Tottenham on home soil in the Premier League, so will be extremely confident of coming out on top in this one, although he will be a little concerned that Utd have a tendancy to look very ordinary, as they did in the first half at Anfield last week.
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There are some defensive concerns also, with Utd conceding five goals in their last four Premiership outings, and with Vidic and Ferdinand once again out with injuries, Tottenham do possess the firepower to worry Sir Alex.
Should results go their way on Saturday, the Red Devils could move to the top of the table by the time the final whistle goes.
As for Tottenham, (best price 11/2 with Paddy Power) they are not a side to come here to make up the numbers and just be happy with a good performance.
For Spurs, it is all about making the top four again this season and if they are to do that, then they must pick up points at the big sides.
They come into this one on the back of three straight victories and seem to have some confidence in the camp, as Andre Villas-Boas looks to be getting his side to play the way he wants them to.
There are also some new faces at White Hart Lane this season, most notably Clint Dempsey and Moussa Dembele, and together with Gareth Bale this trio could cause problems for the United back line, already without Nemanja Vidic, who is out for eight weeks with a knee problem.
Jermain Defoe has been at his prolific best in the league this season and has hit the back of the net four times already.
It seems if you give the Englishman a chance right now, he is likely to take it.
With so much attacking talent on show, this is sure to be a cracker.